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ARTHRITIS INFORMATION

Rheumatic diseases can affect any part of the body and take many forms, including all types of arthritis, such as rheumatoid arthritis and osteoarthritis; autoimmune diseases, such as systemic lupus and scleroderma; osteoporosis; fibromyalgia; gout; and tendonitis.


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Scleroderma

What is Scleroderma?
Scleroderma is a chronic autoimmune disease that was first described in the 18th century. The term scleroderma means "hard skin," which describes thickening of the skin from increased deposits of collagen.

There are two types of scleroderma. Localized scleroderma affects the skin in limited areas and the musculoskeletal system. Systemic sclerosis causes more widespread skin changes and may be associated with internal organ damage in the lungs, heart and kidneys. It can cause arthritis, slow contractions in the gastrointestinal tract, muscle inflammation, dry eyes and dry mouth. Most people with scleroderma have cold-induced spasms of small blood vessels in their hands or feet, known as Raynaud's phenomenon, which caused the fingers or toes to turn white or blue and may be painful.

Cause
In most cases, the cause of scleroderma is unknown. However, in a small minority of cases, scleroderma or scleroderma-like illnesses are associated with exposure to certain toxins or as a complication of bone marrow transplants. Scleroderma is not contagious and is rarely inherited.

Systemic sclerosis is associated with over-activation of the immune system, which normally functions to protect the body against cancers and invading infections. This causes damage to cells that line small blood vessels, which in turn leads to the over-production of scar tissue.

Health Impact

  • Scleroderma affects women more than men and adults more than children.
  • 10-20 new cases are diagnosed per million people each year.
  • Five-year survival rate is 80 – 85 percent.
  • Lung, heart and kidney damage are the most frequent causes of severe disability and death.
  • Many people have decreased hand function because of joint disfigurement or finger ulcers.

Diagnosis
Diagnosis of scleroderma is based on clinical history and physical findings. Diagnosis may be delayed in those without significant skin thickening. Laboratory, X-ray and pulmonary function tests determine the extent and severity of internal organ involvement.

Treatment
There is no known cure for scleroderma. No treatment has been scientifically proven to alter the overall course of the disease, although d-penicillamine is commonly used for this purpose and may be of some value.

There are a number of effective organ-specific treatments for scleroderma. Raynaud's phenomenon may be helped by calcium channel blockers. Declining renal function and hypertension are often treated with drugs. Esophageal damage from reflux of stomach contents can be treated with acid-reducing drugs. Antibiotics, special diets and medication can improve absorption of nutrients in people who have abnormalities of their intestines. Musculoskeletal pain may respond to nonsteroidal

Currently, the Columbus Arthritis Center represents one of the largest rheumatology specific centers in the nation.